What is Centronuclear myopathy dogs?
Centronuclear myopathy is a hereditary myopathy of Labrador Retrievers characterized by generalized loss of muscle tone and control. Phenotype: Signs of centronuclear myopathy include generalized loss of muscle tone and control, exercise intolerance, and an awkward gait.
What does EIC carrier mean?
EIC episodes generally occur after 5-25 minutes of extreme exercise. This means that a dog can have one copy of the mutation and not experience any signs or symptoms of EIC; this dog would be known as a carrier. The carrier can then pass on either the normal gene or the mutated gene to any offspring.
What does CNM stand for in dogs?
Description: Centronuclear Myopathy (CNM), previously known as HMLR, or Hereditary Myopathy, is an autosomal recessive mutation that causes insufficient muscle function in the Labrador Retriever breed. This is due to the centralisation of the nuclei in muscle fibers, caused by a missense insertion in the PTPLA gene.
Can a dog be tested for centronuclear myopathy?
Animal Genetics UK offers DNA testing for Centronuclear Myopathy (CNM). The genetic test verifies the presence of the recessive CNM mutation and presents results as one of the following: The dog carries two copies of the mutant gene and is homozygous for Centronuclear Myopathy.
Can you test a Labrador Retriever for CNM?
Testing for CNM can assist clinicians, owners, and breeders in identifying affected and carrier dogs. Breeders can use results from the test as a tool for selection of mating pairs to avoid producing affected dogs. Note: This test is specific for the CNM mutation described in Labrador Retrievers. No copies of CNM mutation detected. Dog is normal.
Do you have to have two copies of centronuclear myopathy?
Centronuclear myopathy is a recessive disorder, meaning that the dog must have two copies (CNM/CNM) of the defective gene to suffer from the disease. A dog can also be a carrier (CNM/n) of this disease, and will not display any symptoms.
What kind of myopathy does a Labrador Retriever have?
Dogs with CNM/CNM genotype will have centronuclear myopathy. Centronuclear myopathy (CNM) is a hereditary myopathy of Labrador Retrievers resulting from a mutation in the protein tyrosine phosphatase-like member A gene ( PTPLA ).
Can a Labrador Retriever have centronuclear myopathy?
CNM typically manifests in puppies at 2-5 months of age. Dogs with N/N genotype will not have centronuclear myopathy and cannot transmit this CNM variant to their offspring.
Testing for CNM can assist clinicians, owners, and breeders in identifying affected and carrier dogs. Breeders can use results from the test as a tool for selection of mating pairs to avoid producing affected dogs. Note: This test is specific for the CNM mutation described in Labrador Retrievers. No copies of CNM mutation detected. Dog is normal.
What is X-linked myotubular myopathy in Labrador Retrievers?
X-linked myotubular myopathy in Labrador Retrievers is an inherited muscle disease that manifests with generalized muscle weakness and progressive muscle atrophy in puppies.
How many copies of CNM can a dog have?
Type of Test Test Result Centronuclear Myopathy N/N No copies of CNM mutation detected. Dog N/CNM 1 copy of CNM mutation. Dog is a carrier CNM/CNM 2 copies of CNM mutation. Dog is affecte
What is PRA Prcd in dogs?
Progressive rod-cone degeneration (PRCD) is an inherited form of late-onset progressive retinal atrophy (PRA) that has been identified in many dog breeds. The cells of the retina involved in low light vision, known as rods, are affected first, resulting in night blindness.
