What does high GGT mean in dogs?
Increased GGT production, and therefore increased serum concentrations of GGT, are found in liver conditions that result in cholestasis (impaired bile flow), especially those conditions resulting in increased growth or proliferation of bile ducts. Steroid containing drugs may also increase serum GGT concentrations.
What does elevated ALP mean in dogs?
An increase in serum alkaline phosphatase (ALP) activity is a common laboratory finding in dogs. It is typically used as a diagnostic marker for cholestatic liver disease. However, increased ALP activity has a high sensitivity (86%) but poor specificity (49%) for canine liver disease.
What does high GGT and ALP mean?
An elevated ALP with a low or normal GGT means the increased ALP is more likely due to bone disease. An elevated GGT level suggests that a condition or disease is damaging the liver but does not indicate specifically the cause of the damage. In general, the higher the level, the greater the damage to the liver.
What do the abnormal GGT and alkaline phosphatase indicate?
High levels of ALP and high levels of GGT means your symptoms are likely due to liver disorder and not a bone disorder. High levels of ALP and low or normal GGT means it’s more likely you have a bone disorder.
What is considered a very high GGT level?
In adults, GGT levels in the range of 0 to 30 IU/L are normal. Anything above 30 IU/L could be a sign that your liver isn’t working the way it should. Several types of liver disease can cause a rise in GGT, including: Viral hepatitis.
Is GGT elevated in fatty liver?
Frequently elevated GGT levels can be evaluated as a significant factor for changes in fatty liver. Elevated GGT in non-alcohol drinkers is sometimes a surrogate marker for fatty liver [13, 14]. Our data suggest that frequently elevated GGT levels are probably a good predictor of fatty liver changes to come.
How long does it take for gamma GT to return to normal?
TRADITIONAL BIOMARKERS
| Marker | Time to return to normal limits |
|---|---|
| Gamma–glutamyltransferase | 2–6 weeks of abstinence |
| Aspartate aminotransferase | 7 days, but considerable variability in declines with abstinence |
| Alanine aminotransferase | Unknown |
| Macrocytic volume | Unknown but half–life ∼ 40 days |
How long after drinking does the GGT go down?
Gamma–Glutamyltransferase Levels typically rise after heavy alcohol intake that has continued for several weeks (Allen et al. 1994). With 2–6 weeks of abstinence, levels generally decrease to within the normal reference range, with the half–life of GGT being 14–26 days.
When should I be concerned about GGT?
What is a high GGT result?
High levels of GGT in the blood could indicate that the enzyme is leaking out of the liver cells and into the blood, suggesting damage to the liver or bile ducts. A typical range for GGT levels in adults and children is between 0 and 30 international units per liter (IU/L).
What level of GGT is normal?
