What is the most common symptom of theophylline toxicity?
Clinical manifestations of acute theophylline overdose are as follows: Nausea. Vomiting. Abdominal pain.
What is aminophylline toxicity?
Aminophylline is a useful but a potentially toxic drug which may cause severe reactions or even death, due usually to overdosage of or possibly hypersensitivity to the drug. 3. The earliest and most constant symptom of toxicity is restlessness. The next important and almost constant symptom is frequent vomiting.
What happens if aminophylline infusion too rapidly?
Too rapid intravenous administration may result in the following symptoms: anxiety, headache, nausea and vomiting, severe hypotension, dizziness, faintness, lightheadedness, palpitations, syncope, precordial pain, flushing, profound bradycardia, premature ventricular contractions, cardiac arrest.
What are the contraindications of aminophylline?
Aminophylline contraindications include patients with hypersensitivity to theophylline, ethylenediamine, or any component of the drug formulation. Precautions are necessary for patients with concurrent illnesses like: Cardiac disease. Renal Impairment.
Which aminophylline level is associated with signs of toxicity?
Therapeutic serum levels range from 10-20 mcg/mL. Toxic levels are considered to be higher than 20 mcg/mL; however, adverse effects may be evident within the normal therapeutic range. Severe complications including cardiac dysrhythmias, seizures, and death can be observed with levels of 80-100 mcg/mL.
What is the antidote for aminophylline?
Activated charcoal. Intravenous fluids (given through a vein) Laxative. Medicine to treat symptoms.
Can aminophylline be given IV push?
Aminophylline Injection is administered by slow intravenous injection or diluted and administered by intravenous infusion. The solution contains no bacteriostat or antimicrobial agent and is intended for use only as a single-dose injection. When smaller doses are required the unused portion should be discarded.
How long does aminophylline stay in your system?
These include Aminophylline, Choledyl, Oxtryphylline. Long-acting last for 12 hours. These include Choledyl SA, Phyllocontin, Somophyllin, Theo-Dur, Theolair SR. Other: Some act for 24 hours such as Uniphyl.
Is aminophylline short or long acting?
Short-acting last for 4 to 6 hours. These include Aminophylline, Choledyl, Oxtryphylline. Long-acting last for 12 hours.
What causes theophylline toxicity?
Therefore, Theophylline toxicity occurs when serum theophylline levels surpass the levels in the therapeutic range. This can occur by intentional overdose or unintentionally when metabolism and/or clearance of theophylline is altered due to certain physiological stressors.
Does theophylline increase heart rate?
In noncontrolled studies performed in patients with symptomatic SSS, oral theophylline increased resting and exercise heart rate, improved symptoms, and reduced cardiac pauses during follow-up.
