What is the shelf life of buprenorphine?
EXPIRATION OF DILUTED PREPARATIONS- not to exceed 30 days. Use aseptic technique for removing and administering buprenorphine. The expiration of the original solution prevails when dating diluted solutions. Buprenorphine is an effective analgesic to manage pain in rodents.
Does compounded buprenorphine need to be refrigerated?
How do I store buprenorphine? Store at room temperature between 20°C and 25°C (68°F and 77°F) and protected from light, excessive heat above 40°C (104°F), and freezing. Follow the storage directions on the label for compounded forms of this medication.
Is Buprenex safe for humans?
Although Buprenex is an FDA-approved medication, it has serious warnings and side effects and can be fatal if abused, taken in too high or a dose, or combined with other medicines that can increase sedation or respiratory depression (slowed breathing).
How is Buprenex injected into a muscle?
Buprenex is injected into a muscle or given as an infusion into a vein. A healthcare provider will give you this injection. Buprenex is usually given by injection only if you are unable to take the medicine by mouth or use another form of buprenorphine.
How often does Buprenex have to be given?
Buprenex is injected into a muscle or given as an infusion into a vein. A healthcare provider will give you this injection. Buprenex is usually given by injection only if you are unable to take the medicine by mouth or use another form of buprenorphine. Buprenex is usually given at evenly spaced intervals, up to 6 hours apart.
When to take buprenephine after taking an injection?
Buprenex is usually given by injection only if you are unable to take the medicine by mouth or use another form of buprenorphine. Buprenex is usually given at evenly spaced intervals, up to 6 hours apart. Tell your doctor if Buprenex does not relieve your pain within 1 hour after an injection.
What are the side effects of Buprenex injections?
Common side effects may include: drowsiness; constipation; dizziness, spinning sensation; nausea, vomiting; increased sweating; headache; or blurred vision, double vision.
What do you need to know about buprenorphine injections?
Buprenorphine hydrochloride is a white powder, weakly acidic and with limited solubility in water. Buprenorphine hydrochloride injection is a clear, sterile, injectable agonist-antagonist analgesic intended for intravenous or intramuscular administration.
How is buprenorphine clearance related to glucuronidation?
Buprenorphine undergoes both N-dealkylation to norbuprenorphine and glucuronidation. The N-dealkylation pathway is mediated primarily by CYP3A4. Norbuprenorphine, the major metabolite, can further undergo glucuronidation. Its clearance is related to hepatic blood flow.
When to use buprenorphine HCl injection in asthma patients?
Buprenorphine HCl Injection is contraindicated in patients with: Significant respiratory depression [See WARNINGS ]. Acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment [See WARNINGS ]. Known or suspected gastrointestinal obstruction, including paralytic ileus [See WARNINGS ].
What is the molecular formula of buprenorphine hydrochloride?
Buprenorphine hydrochloride has the molecular formula, C 29 H 41 NO 4 HCl, and the following structure: Molecular weight: 504.10 Buprenorphine is a partial agonist at the mu-opioid receptor and an antagonist at the kappa-opioid receptor.
