How is the dose of a toxin calculated?
The amount of a substance, bacterium, or toxin that will kill 50% of the animals exposed to it. Dose is usually calculated on amount of material given per gram or kilogram of body weight or amount per unit of body surface area.
What is the definition of td 50 toxicology?
TD 50 Toxicology The calculated dose of a chemical introduced by a route other than inhalation, that would cause a specific toxic effect in 50% of a defined experimental animal population Cf Lethal concentration, Lethal dose. Minimal dose required to produce adverse effects. 1.
Which is the best definition of a toxic dose?
1. Radiation absorbed dose. 2. The amount of a substance ingested, inhaled, or taken up through any protective surface into the body The intensity of radiation measured in air at the target. Any dose, e.g., of a vaccine, administered to a neonate. The term is commonly used to describe a neonatal injection of hepatitis B vaccine.
Are there different levels of toxicity in people?
Obviously, there are different levels of toxicity. Some people are highly toxic, leaving everyone worse off with even brief meetings. Others cause harm over a longer period of time.
What does dose limiting toxicity mean?
The determination of the MTD is based on the occurrence of the DLT (dose limiting toxicity), Dose-Limiting toxicity is defined to be a toxicity that prevents further administration of the agent at that dose level.
What is repeated dose toxicity?
Repeated dose toxicity. Repeated dose toxicity comprises the adverse general toxicological effects occurring as a result of repeated daily exposure dose to a substance for a specified period up to the expected lifespan of the test species. The studies yield information on general characteristics of the toxicity, the target organs of toxicity,…
What is the definition of toxic dose?
toxic dose. Quantity at which a solid, water-insoluble substance produces harmful effects in a specified test specie over a stated exposure period.
What is toxic dose 50?
In toxicology, the median toxic dose (TD 50) of a drug or toxin is the dose at which toxicity occurs in 50% of cases. The type of toxicity should be specified for this value to have meaning for practical purposes.
