What is Hepatoprotective medicine?
Hepatoprotective drugs means the drugs that are prevent the liver disease. Hepatotoxicity has now become the most serious liver disorder, which accounts for about 15% of the world’s burden of diseases.
Which Phytoconstituents are Hepatoprotective in nature?
These hepatoprotective plants have the phytoconstituents such as phenyl compounds, coumarins, essential oils, monoterpenoids, diterpenoids, triterpenoids, steroids, alkaloids and other nitrogenous compounds.
What drugs cause hepatotoxicity?
The 10 most frequently implicated drugs were: amoxicillin-clavulanate, flucloxacillin, erythromycin, diclofenac, sulfamethoxazole/Trimethoprim, isoniazid, disulfiram, Ibuprofen and flutamide [12,13,14,21].
Is milk thistle a silymarin?
Milk thistle (silymarin) is a flowering herb related to the daisy and ragweed family. It is native to Mediterranean countries. Some people also call it Mary thistle and holy thistle.
Is it safe to take milk thistle daily?
Generally, it’s safe to take milk thistle in recommended doses. Some people have reported nausea, gas, diarrhea, or loss of appetite. Other people have reported a headache or itchiness after they take it. Milk thistle can cause an allergic reaction, especially if you’re allergic to other plants in the same family.
Can milk thistle reverse liver damage?
Milk thistle will not reverse existing liver damage, and it will not cure infection with the hepatitis B or hepatitis C virus. Milk thistle should not be used by people who have complications from cirrhosis (such as variceal bleeding or ascites).
What are phytochemicals and what is their function?
Phytochemicals are compounds that are produced by plants (“phyto” means “plant”). They are found in fruits, vegetables, grains, beans, and other plants. Some of these phytochemicals are believed to protect cells from damage that could lead to cancer.
What are the types of phytochemicals?
Generally, phytochemicals have been classified into six major categories based on their chemical structures and characteristics. These categories include carbohydrate, lipids, phenolics, terpenoids and alkaloids, and other nitrogen-containing compounds (Figure 1; Harborne and Baxter, 1993; Campos-Vega and Oomah, 2013).
Can you take silymarin daily?
Dosing. BY MOUTH: For diabetes: Milk thistle extract 210-600 mg has been used daily for up to 6 months. 200 mg of milk thistle extract has been taken once daily or three times daily for 4 months to one year.
How can I detox my liver fast?
How Do You Flush Out Your Liver?
- Flush out with plenty of water intake: Water is the best flushing agent.
- Get regular exercise: Exercise helps to burn extra calories that reduce your risk of diabetes, excess weight, high blood pressure, and high blood fat.
Is it OK to take milk thistle every day?
Is Milk Thistle Safe? Milk thistle is generally considered safe when taken by mouth ( 1 , 45 ). In fact, in studies where high doses were used for long periods, only about 1% of people experienced side effects ( 1 ).
How do you say hepatoprotective?
hep·ato·pro·tec·tive.
What is the mechanism of hepatoprotection in the liver?
The mechanism of hepatoprotection by these compounds is generally by exerting multiple effects. The herbal drugs used for the management of chronic liver disease can regulate and strengthen the liver, gastrointestinal and immune system (Seeff et al., 2001 ).
Which is a significant source of hepatoprotective drugs?
ABSTRACT Article Received on Medicinal plants are significant source of Hepatoprotective drugs. 17 March 2012, Mono and poly-herbal preparations have been used in various liver Revised on 31 March 2012, disorders since ages.
Which is better a hepatotoxic drug or a herbal drug?
A drug having beneficial effect on the liver is known as hepatoprotective drug. On the other hand, drugs having toxic affect on the liver are better known as hepatotoxic drugs. Clinical research has also shown that herbals have genuine utility in the treatment of liver diseases.
Which is the safest hepatoprotective agent in the world?
Hence, there is an ever increasing need for safe hepatoprotective agent. Silymarin is a potent hepatoprotective drug having established place in hepatology practice. Silymarin is a flavono-lignan mixture obtained from seeds of Silybum marianum. Silymarin is a mixture of silybin, isosilybin, silychristin and silydianin.
The mechanism of hepatoprotection by these compounds is generally by exerting multiple effects. The herbal drugs used for the management of chronic liver disease can regulate and strengthen the liver, gastrointestinal and immune system (Seeff et al., 2001 ).
What foods reduce the risk of hepatoprotective disease?
Mainly cholesterol or lecithin rich dietary fats enhances the risk of cholelithiasis while omega-3/omega-6 fatty acids reduce the risk of bile lithogenicity and play hepatoprotective role in primary, secondary and late onset diseases (Sharma and Singh, 2010).
How does curcumin protect against hepatoprotection of the liver?
Curcumin exhibits hepatoprotection similar to that of glycyrrhizin and silymarin (see Chapters 96 and 123Chapter 123Chapter 96, respectively, for further discussion) against carbon tetrachloride and galactosamine-induced liver injury.28 This protection is largely a result of its potent antioxidant activity.
Which is the best drug for hepatoprotection in mice?
Mice given intraperitoneal injections of the hepatoxic drugs carbon tetrachloride (32 mg/kg) and acetaminophen (600 mg/kg) experienced significantly decreased liver damage, as measured by serum glutamate oxaloacetate and serum glutamate pyruvate transaminase, when treated with 100 mg/kg of turmeric.29
