What does it mean when PT and PTT are high?

A prolonged PT means that the blood is taking too long to form a clot. This may be caused by conditions such as liver disease, vitamin K deficiency, or a coagulation factor deficiency (e.g., factor VII deficiency). The PT result is often interpreted with that of the PTT in determining what condition may be present.

What causes PT PTT to be high?

For patients with deficiencies or defects of the intrinsic clotting cascade, the PTT will be elevated. Disorders with an elevated PTT include: Hemophilia A (Factor VIII deficiency) Hemophilia B (Factor IX deficiency)

What does a high PT and aPTT mean?

A normal PT with an abnormal aPTT means that the defect lies within the intrinsic pathway, and a deficiency of factor VIII, IX, X, or XIII is suggested. A normal aPTT with an abnormal PT means that the defect lies within the extrinsic pathway and suggests a possible factor VII deficiency.

What is considered a high PTT level?

A typical aPTT value is 30 to 40 seconds. If you get the test because you’re taking heparin, you’d want your PTT results to be more like 120 to 140 seconds, and your aPTT to be 60 to 80 seconds. If your number is higher than normal, it could mean several things, from a bleeding disorder to liver disease.

Is PT and PTT the same?

Two laboratory tests are used commonly to evaluate coagulation disorders: Prothrombin Time (PT) which measures the integrity of the extrinsic system as well as factors common to both systems and Partial Thromboplastin Time (PTT), which measures the integrity of the intrinsic system and the common components.

What happens if APTT is high?

A prolonged aPTT usually means that clotting is taking longer to occur than expected (but is associated with increased risk of blood clots if due to a lupus anticoagulant) and may be caused by a variety of factors (see the list below).

What is difference between PT and PTT?

What is the normal range for aPTT test?

A normal range is around 25 to 35 seconds, but test results will vary depending on equipment and methods used. Therefore, standard normal results will differ in each lab. If your aPTT takes longer than usual, it may mean several things.

What is normal PT and PTT levels?

Normal Values for Coagulation Tests

PT 10-12 seconds
PTT 30-45 seconds
INR 1:2 ratio

What is the normal range of PT?

Normal Results PT is measured in seconds. Most of the time, results are given as what is called INR (international normalized ratio). If you are not taking blood thinning medicines, such as warfarin, the normal range for your PT results is: 11 to 13.5 seconds.

What is normal clotting time?

The normal clotting time in a person is between 8-15 minutes. By understanding the time taken for blood to clot, it can be determined if the person has haemophilia or von Willibrand’s disease. Bleeding time normal range can still be considered between a one1 minute to eight minutes.

What does elevated PTT mean on a blood test?

This may indicate extensive cancer, unless there is known liver issue involved. It may also indicate an acute phase reaction that is causing a pronounced level of inflammation within the body that immediately elevates a specific factor level. Acute reactions will cause future PTT blood tests to return to a normal range.

Are there any laboratory tests for prolonged PTT?

Appropriate laboratory test selection is more difficult than apparent to many physicians, even experts in specialty fields of medicine. While everyone is familiar with the PT and the PTT, follow‐up evaluation of a patient with one or both prolonged requires knowledge of a number of very different possibilities.

What are the causes of abnormal PT and PTT?

Liver disease (early / mild) DIC (early) Vitamin K deficiency. aPTT evaluates clotting within the intrinsic and common coagulation pathways. Causes of isolated prolonged aPTT ( Lab Med 2017;48:295, Semin Thromb Hemost 2014;40:195, Am J Hematol 2013;88:82 ): Deficiency of or inhibitor to factors VIII, IX, or XI.

What’s the difference between normal PT and PTT?

When combined together, these PT and PTT results may indicate these common conditions. Prolonged PT, Normal PTT: Indicates a vitamin K deficiency, decreased/defective factors, or liver disease. Normal PT, Prolonged PTT: Indicates hemophilia, certain defective factors, von Willebrand disease, or the presence of a lupus anticoagulant.